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Data da postagem: 17/12/2020
Applying an association weight matrix in weighted genomic prediction of boar taint compounds
Autores: Margareth E. Botelho, Marcos S. Lopes, Pramod K. Mathur, Egbert F. Knol, Simone E. F. Guimarães, Daniele B. D. Marques, Paulo S. Lopes, Fabyano F. Silva, Renata Veroneze
Revista: Journal of Animal Breeding and Genetics (Dez/2020)
Abstract: Biological information regarding markers and gene association may be used to attribute different weights for single nucleotide polymorphism (SNP) in genome‐wide selection. Therefore, we aimed to evaluate the predictive ability and the bias of genomic prediction using models that allow SNP weighting in the genomic relationship matrix (G) building, with and without incorporating biological information to obtain the weights. Firstly, we performed a genome‐wide association studies (GWAS) in data set containing single‐ (SL) or a multi‐line (ML) pig population for androstenone, skatole and indole levels. Secondly, 1%, 2%, 5%, 10%, 30% and 50% of the markers explaining the highest proportions of the genetic variance for each trait were selected to build gene networks through the association weight matrix (AWM) approach. The number of edges in the network was computed and used to derive weights for G (AWM‐WssGBLUP). The single‐step GBLUP (ssGBLUP) and weighted ssGBLUP (WssGBLUP) were used as standard scenarios. All scenarios presented predictive abilities different from zero; however, the great overlap in their confidences interval suggests no differences among scenarios. Most of scenarios of based on AWM provide overestimations for skatole in both SL and ML populations. On the other hand, the skatole and indole prediction were no biased in the ssGBLUP (S1) in both SL and ML populations. Most of scenarios based on AWM provide no biased predictions for indole in both SL and ML populations. In summary, using biological information through AWM matrix and gene networks to derive weights for genomic prediction resulted in no increase in predictive ability for boar taint compounds. In addition, this approach increased the number of analyses steps. Thus, we can conclude that ssGBLUP is most appropriate for the analysis of boar taint compounds in comparison with the weighted strategies used in the present work.